Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia - Wikidata - wikimedia - TriplyDB

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

http://www.wikidata.org/entity/Q24670279

about

The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation New insight into the molecular mechanisms of MLL-associated leukemia Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues Rho GTPases in hematopoiesis and hemopathies Approaches of targeting Rho GTPases in cancer drug discovery Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae.Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA B plexins activate Rho through PDZ-RhoGEF Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells RHO-GTPases and cancer The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Hematopoietic gene expression profile in zebrafish kidney marrow.Influence of simulated microgravity on the activation of the small GTPase Rho involved in cytoskeletal formation--molecular cloning and sequencing of bovine leukemia-associated guanine nucleotide exchange factor Molecular characterization of spontaneous mesenchymal stem cell transformation High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Diagnostic tool for the identification of MLL rearrangements including unknown partner genes LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells.Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisom Mdr1 gene expression and mutations in Ras proto-oncogenes in acute myeloid leukemia.Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.Rho GTPase-dependent transformation by G protein-coupled receptors.Prognostic significance of 11q23 aberrations in adult acute myeloid leukemia and the role of allogeneic stem cell transplantation.Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.

P2860

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P2860

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

http://www.wikidata.org/entity/Q24670279

description

2000 nî lūn-bûn

@nan

2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի փետրվարին հրատարակված գիտական հոդված

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2000年の論文

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2000年学术文章

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2000年学术文章

@zh-cn

2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年學術文章

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name

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@ast

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@en

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

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type

label

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@ast

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@en

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@nl

prefLabel

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@ast

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@en

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@nl

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Identification of a gene at 11 ...... MLL in acute myeloid leukemia

@en

P2093

B Becknell

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K S Theil

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M A Caligiuri

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M L Veronese

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M P Strout

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P J Kourlas

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R Krahe

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S Knuutila

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T Ruutu

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P2860

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

Rho GTPases and the actin cytoskeleton

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2145-50

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scholarly article

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1863365

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10.1073/PNAS.040569197

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5

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P478

97

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Clara D. Bloomfield

Carlo Maria Croce

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2000-02-29T00:00:00Z

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12634930

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10681437

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15768

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