Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2 - Wikidata - wikimedia - TriplyDB

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

http://www.wikidata.org/entity/Q24671925

about

Molecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseases Fine tuning of the UPR by the ubiquitin ligases Siah1/2.Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies.The ubiquitin ligase Siah2 and the hypoxia response.Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity.Inhibition of Siah ubiquitin ligase function.The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes.The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress.Seven in absentia homolog 2 (Siah2) protein is a regulator of NF-E2-related factor 2 (Nrf2)EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression.Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein Role of E3 ubiquitin ligases in insulin resistance.Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide.Angiotensin II differentially regulates Morg1 expression in kidney cells.Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases.

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P2860

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

http://www.wikidata.org/entity/Q24671925

description

2007 nî lūn-bûn

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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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Hypoxia-induced assembly of pr ...... adation by the E3 ligase Siah2

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Hypoxia-induced assembly of pr ...... adation by the E3 ligase Siah2

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Hypoxia-induced assembly of pr ...... adation by the E3 ligase Siah2

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Hypoxia-induced assembly of pr ...... adation by the E3 ligase Siah2

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Hypoxia-induced assembly of pr ...... adation by the E3 ligase Siah2

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Hypoxia-induced assembly of pr ...... adation by the E3 ligase Siah2

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Hypoxia-induced assembly of pr ...... adation by the E3 ligase Siah2

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Koh Nakayama

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Robert Abraham

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Stefan Gazdoiu

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Zhen-Qiang Pan

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P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.

Stress-induced decrease in TRAF2 stability is mediated by Siah2

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

Targeting HIF-1 for cancer therapy

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10.1042/BJ20061135

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