Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
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Phosphorylation of grb10 regulates its interaction with 14-3-3Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptorGrb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradationPhosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptorNedd4 controls animal growth by regulating IGF-1 signalingThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2Psychosis and autism as diametrical disorders of the social brainNegative regulators of insulin signaling revealed in a genome-wide functional screenTissue-specific regulation and function of Grb10 during growth and neuronal commitment.Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.Endoplasmic reticulum (ER) localization is critical for DsbA-L protein to suppress ER stress and adiponectin down-regulation in adipocytesThe cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner.An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinismCarrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1Cloning and transgenesis in mammals: implications for xenotransplantation.Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling.Grb10 and Grb14: enigmatic regulators of insulin action--and more?Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.Adapter protein connections: the MRL and Grb7 protein families.Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization.Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.Inputs and outputs of insulin receptor.Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells.Molecular mechanisms of genomic imprinting and clinical implications for cancer.Grb10 is a dual regulator of receptor tyrosine kinase signaling.FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemiaThe TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.Epidermal growth factor and/or growth hormone induce differential, side-specific signal transduction protein phosphorylation in enterocytes.Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.The TSC-mTOR pathway regulates macrophage polarization.Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance.Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway.
P2860
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P2860
Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Grb10 inhibits insulin-stimula ...... S-2 with the insulin receptor.
@en
type
label
Grb10 inhibits insulin-stimula ...... S-2 with the insulin receptor.
@en
prefLabel
Grb10 inhibits insulin-stimula ...... S-2 with the insulin receptor.
@en
P2093
P2860
P356
P1476
Grb10 inhibits insulin-stimula ...... S-2 with the insulin receptor.
@en
P2093
Eric D Werner
Fresnida J Ramos
KeriLyn R Wick
Lily Q Dong
Paul Langlais
Steven E Shoelson
P2860
P304
P356
10.1074/JBC.M208518200
P407
P577
2002-12-18T00:00:00Z