Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release
about
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.)NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinonesExpansion of substrate specificity and catalytic mechanism of azoreductase by X-ray crystallography and site-directed mutagenesisThe structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge ConformationMechanistic and structural basis for inhibition of thymidylate synthase ThyXStructures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding siteLot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification.Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotectorMechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approachesInduction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and eStructure determination of an FMN reductase from Pseudomonas aeruginosa PA01 using sulfur anomalous signalNovel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosisA systems biology perspective on Nrf2-mediated antioxidant responseRelationships between metabolic and non-metabolic susceptibility factors in benzene toxicity.Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation.NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells.Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung.Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrateHuman NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups.Quinone reductase 2 is a catechol quinone reductaseCoenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxiaThe Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)A structurally conserved water molecule in Rossmann dinucleotide-binding domains.Azoreductases in drug metabolism.Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch.Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species.Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.Quinone oxidoreductase-2-mediated prodrug cancer therapy.HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism.Redox modulation of NQO1.Three-dimensional structure of AzoR from Escherichia coli. An oxidereductase conserved in microorganisms.Evolutionary Divergent Suppressor Mutations in Conformational DiseasesSuperoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) fromYarrowia lipolytica
P2860
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P2860
Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structures of recombinant huma ...... substrate binding and release
@ast
Structures of recombinant huma ...... substrate binding and release
@en
Structures of recombinant huma ...... substrate binding and release
@nl
type
label
Structures of recombinant huma ...... substrate binding and release
@ast
Structures of recombinant huma ...... substrate binding and release
@en
Structures of recombinant huma ...... substrate binding and release
@nl
altLabel
Structures of recombinant huma ...... substrate binding and release
@en
prefLabel
Structures of recombinant huma ...... substrate binding and release
@ast
Structures of recombinant huma ...... substrate binding and release
@en
Structures of recombinant huma ...... substrate binding and release
@nl
P2093
P2860
P3181
P356
P1476
Structures of recombinant huma ...... substrate binding and release
@en
P2093
M A Bianchet
P2860
P304
P3181
P356
10.1073/PNAS.050585797
P407
P577
2000-03-28T00:00:00Z