HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism.
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The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substratesStructure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generationType-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reductionFunctional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondriaMycobacterium tuberculosis type II NADH-menaquinone oxidoreductase catalyzes electron transfer through a two-site ping-pong mechanism and has two quinone-binding sitesIn vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii.Quinolones: from antibiotics to autoinducers.Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae: evidence for a ternary complex mechanism.Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase.Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.The Ca2+-Regulation of the Mitochondrial External NADPH Dehydrogenase in Plants Is Controlled by Cytosolic pH.HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.Drugs in development for toxoplasmosis: advances, challenges, and current status.A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activityThe mechanism of catalysis by type-II NADH:quinone oxidoreductases.Two internal type II NADH dehydrogenases of Toxoplasma gondii are both required for optimal tachyzoite growth.Type II NADH:quinone oxidoreductase family: phylogenetic distribution, structural diversity and evolutionary divergences.Type II NADH dehydrogenase inhibitor 1-hydroxy-2-dodecyl-4(1H)quinolone leads to collapse of mitochondrial inner-membrane potential and ATP depletion in Toxoplasma gondii.Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species.Bioenergetics of the moderately halophilic bacterium Halobacillus halophilus: composition and regulation of the respiratory chain.Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenasesRoles of bound quinone in the single subunit NADH-quinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae.Mitochondrial dehydrogenases in the aerobic respiratory chain of the rodent malaria parasite Plasmodium yoelii yoelii.Na+-NQR (Na+-translocating NADH:ubiquinone oxidoreductase) as a novel target for antibiotics.Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2).Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors.New complexes containing the internal alternative NADH dehydrogenase (Ndi1) in mitochondria of Saccharomyces cerevisiae.Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.Exploring the Ubiquinone Binding Cavity of Respiratory Complex ISuperoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) fromYarrowia lipolytica
P2860
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P2860
HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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name
HDQ (1-hydroxy-2-dodecyl-4(1H) ...... nce for a ping-pong mechanism.
@en
HDQ (1-hydroxy-2-dodecyl-4(1H) ...... nce for a ping-pong mechanism.
@nl
type
label
HDQ (1-hydroxy-2-dodecyl-4(1H) ...... nce for a ping-pong mechanism.
@en
HDQ (1-hydroxy-2-dodecyl-4(1H) ...... nce for a ping-pong mechanism.
@nl
prefLabel
HDQ (1-hydroxy-2-dodecyl-4(1H) ...... nce for a ping-pong mechanism.
@en
HDQ (1-hydroxy-2-dodecyl-4(1H) ...... nce for a ping-pong mechanism.
@nl
P2093
P2860
P356
P1476
HDQ (1-hydroxy-2-dodecyl-4(1H) ...... nce for a ping-pong mechanism.
@en
P2093
Alexander Galkin
Andrea Eschemann
Stefan Kerscher
Walter Oettmeier
P2860
P304
P356
10.1074/JBC.M411217200
P407
P577
2004-11-08T00:00:00Z