Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb - Wikidata - wikimedia - TriplyDB

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb

http://www.wikidata.org/entity/Q25255186

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The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription.Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat Reconstitution of a functional 7SK snRNP Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor.Nuclear organization and dynamics of 7SK RNA in regulating gene expression.HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements RNA polymerase II transcription elongation control.The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters.HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.PKC phosphorylates HEXIM1 and regulates P-TEFb activity.The CD8+ cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+ cells Functional interplay between PPM1G and the transcription elongation machinery.7SKiing on chromatin: Move globally, act locally.Steps towards a repertoire of comprehensive maps of human protein interaction networks: the Human Proteotheque Initiative (HuPI)The MORC family: new epigenetic regulators of transcription and DNA damage response.Transcription elongation control by the 7SK snRNP complex: Releasing the pause.HEXIM1, a New Player in the p53 Pathway P-TEFb- the final frontier.U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex.Invertebrate 7SK snRNAs.Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvae Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation.Control of HIV latency by epigenetic and non-epigenetic mechanisms.Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA.MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1 Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb.Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.Evolution of 7SK RNA and its protein partners in metazoa.

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Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb

http://www.wikidata.org/entity/Q25255186

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2005 nî lūn-bûn

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2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Oligomerization of HEXIM1 via ...... rects the inhibition of P-TEFb

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Oligomerization of HEXIM1 via ...... rects the inhibition of P-TEFb

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Oligomerization of HEXIM1 via ...... rects the inhibition of P-TEFb

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Oligomerization of HEXIM1 via ...... rects the inhibition of P-TEFb

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Oligomerization of HEXIM1 via ...... rects the inhibition of P-TEFb

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Oligomerization of HEXIM1 via ...... rects the inhibition of P-TEFb

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B Matija Peterlin

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Dalibor Blazek

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Irena Oven

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Jiri Kohoutek

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Matjaz Barboric

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P2860

Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells

Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription

HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

Classification of human B-ZIP proteins based on dimerization properties

A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

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10.1093/NAR/GKI997

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