PKC phosphorylates HEXIM1 and regulates P-TEFb activity. - Wikidata - wikimedia - TriplyDB

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

http://www.wikidata.org/entity/Q36305691

about

Epigenetic control of HIV-1 post integration latency: implications for therapy Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.RNA polymerase II transcription elongation control.Viral-host interactions that control HIV-1 transcriptional elongation Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells.Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Euphorbia Kansui Reactivates Latent HIV.Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV.Current views on HIV-1 latency, persistence, and cure.Cyclin-dependent kinases as therapeutic targets for HIV-1 infection.The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies.AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions Megakaryocytic irreversible P-TEFb activation.Hexim1, an RNA-controlled protein hub.Bromodomian-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB.SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs.Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.

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P2860

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

http://www.wikidata.org/entity/Q36305691

description

2012 nî lūn-bûn

@nan

2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

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PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

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type

label

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

@ast

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

@en

prefLabel

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

@ast

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

@en

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Nucleic Acids Research

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PKC phosphorylates HEXIM1 and regulates P-TEFb activity

@en

P2093

B Matija Peterlin

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Koh Fujinaga

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Matjaz Barboric

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Zeping Luo

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P2860

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells

A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

c-Myc regulates transcriptional pause release

CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1

7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription

Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

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10.1093/NAR/GKS682

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18

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40

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phosphorylation

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