Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
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EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replicationDeubiquitylating enzymes and diseaseThe deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2USP10 regulates p53 localization and stability by deubiquitinating p53USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-cateninContributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survivalMolecular Basis for Bre5 Cofactor Recognition by the Ubp3 Deubiquitylating EnzymeStructural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase ModuleBilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor proteinA Role for USP7 in DNA ReplicationThe Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiaeModulation of the p53/MDM2 interplay by HAUSP inhibitorsThe shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7Patented small molecule inhibitors in the ubiquitin proteasome systemEpstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies.USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability.Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.Inactivation of HAUSP in vivo modulates p53 function.WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathwayComputational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases.Autoactivation of the MDM2 E3 ligase by intramolecular interaction.Inhibition of interferon induction and action by the nairovirus Nairobi sheep disease virus/Ganjam virus.Mechanism of p53 stabilization by ATM after DNA damage.ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation.New insights into p53 activationStructural insights into the tumor-promoting function of the MTDH-SND1 complex.Roles of HAUSP-mediated p53 regulation in central nervous system development.A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny virusesEstrogen receptor beta impacts hormone-induced alternative mRNA splicing in breast cancer cells.Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNADeubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Deubiquitinating enzymes as novel anticancer targets.STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation.
P2860
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P2860
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@ast
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@en
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@nl
type
label
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@ast
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@en
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@nl
prefLabel
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@ast
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@en
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@nl
P2093
P2860
P1433
P1476
Structural basis of competitiv ...... lation of the p53-MDM2 pathway
@en
P2093
P2860
P356
10.1371/JOURNAL.PBIO.0040027
P407
P50
P577
2006-01-17T00:00:00Z