The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
about
Modulation of Protein-Protein Interactions for the Development of Novel TherapeuticsImpact of Chromatin on HIV ReplicationMultifunctional facets of retrovirus integraseIdentification of novel nuclear targets of human thioredoxin 1Allosteric Inhibition of Human Immunodeficiency Virus IntegraseDual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifStructural Basis for Inhibitor-Induced Aggregation of HIV IntegraseMolecular modeling study on the allosteric inhibition mechanism of HIV-1 integrase by LEDGF/p75 binding site inhibitors.Epigenetic control of mobile DNA as an interface between experience and genome change.Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in Brazilian HIV-1+ individualsZinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging.RNA interference approaches for treatment of HIV-1 infectionNew Frontiers in DruggabilityHIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.Combining a NHS ester and glutaraldehyde improves crosslinking prior to MALDI MS analysis of intact protein complexes.LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase.A Novel Assay for Screening Inhibitors Targeting HIV Integrase LEDGF/p75 Interaction Based on Ni(2+) Coated Magnetic Agarose Beads.LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIVMultiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir.Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes.LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).HIV-1 latency in monocytes/macrophagesAllosteric modulation of protein oligomerization: an emerging approach to drug design.Different Pathways Leading to Integrase Inhibitors ResistanceThe therapeutic landscape of HIV-1 via genome editingPeptide fibrils as monomer storage of the covalent HIV-1 integrase inhibitor.Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors.Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides.Toward a safer integration profile of MLV-based retroviral vectors.Perspectives of Genome-Editing Technologies for HIV Therapy.LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes.Structure based Virtual Screening toward the discovery of novel inhibitors for impeding the protein-protein interaction between HIV-1 integrase and human lens epithelium-derived growth factor (LEDGF/p75).Synthesis, biological evaluation and molecular docking of calix[4]arene-based β-diketo derivatives as HIV-1 integrase inhibitors.Postexposure protection of macaques from vaginal SHIV infection by topical integrase inhibitors.Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations.
P2860
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P2860
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
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2013 nî lūn-bûn
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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2013 թվականի հունվարին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@ast
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@en
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
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type
label
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@ast
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@en
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@nl
prefLabel
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@ast
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@en
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
@nl
P3181
P1433
P1476
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
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P3181
P356
10.1016/J.VIROL.2012.09.033
P407
P577
2013-01-05T00:00:00Z