LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).
about
Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifA critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.New Frontiers in DruggabilityKuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation.A Novel Assay for Screening Inhibitors Targeting HIV Integrase LEDGF/p75 Interaction Based on Ni(2+) Coated Magnetic Agarose Beads.Screening-based approaches to identify small molecules that inhibit protein-protein interactions.Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIVCharacterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting.HIV-1 integrase multimerization as a therapeutic target.The preclinical discovery and development of dolutegravir for the treatment of HIV.Different Pathways Leading to Integrase Inhibitors ResistanceAllosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors.Pyrazolo[1,5-a]pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO2015123182.Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
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P2860
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).
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type
label
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).
@en
prefLabel
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).
@en
P2860
P50
P1476
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).
@en
P2093
Arnaud Marchand
Patrick Chaltin
P2860
P304
P356
10.1517/13543776.2014.898753
P407
P577
2014-03-25T00:00:00Z