about
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)Identification of the LEDGF/p75 binding site in HIV-1 integraseTransient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virusThe LEDGF/p75 integrase interaction, a novel target for anti-HIV therapyRational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replicationStructure of transportin SR2, a karyopherin involved in human disease, in complex with RanCellular co-factors of HIV-1 integrationA symmetric region of the HIV-1 integrase dimerization interface is essential for viral replicationVirus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINsInterplay between HIV entry and transportin-SR2 dependencyLentiviral nuclear import: a complex interplay between virus and host.Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation.Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein.Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.Single-cell imaging of HIV-1 provirus (SCIP).Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitorsLEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIVIn search of small molecules blocking interactions between HIV proteins and intracellular cofactors.Targeting the HIV integration process in antiviral therapy.In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).Host factors for retroviral integration site selection.The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75.Targeting Virus-host Interactions of HIV Replication.Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia.Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication.Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity
P50
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P50
name
Frauke Christ
@en
Frauke Christ
@nl
type
label
Frauke Christ
@en
Frauke Christ
@nl
prefLabel
Frauke Christ
@en
Frauke Christ
@nl