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Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

http://www.wikidata.org/entity/Q27008867

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How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion A scalable method for molecular network reconstruction identifies properties of targets and mutations in acute myeloid leukemia Prediction of Druggable Proteins Using Machine Learning and Systems Biology: A Mini-Review Vasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and Interventions Network-based approaches in drug discovery and early development Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery How do oncoprotein mutations rewire protein-protein interaction networks?Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery Characterization of Protein-Protein Interfaces through a Protein Contact Network Approach Predicting Drug-Target Interactions for New Drug Compounds Using a Weighted Nearest Neighbor Profile Perturbation centrality and turbine: a novel centrality measure obtained using a versatile network dynamics tool Controllability in cancer metabolic networks according to drug targets as driver nodes A novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune system Use of genome-wide association studies for cancer research and drug repositioning Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution Quantitative Determination of Flexible Pharmacological Mechanisms Based On Topological Variation in Mice Anti-Ischemic Modular Networks A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF A Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer Extracting research-quality phenotypes from electronic health records to support precision medicine PhIN: A Protein Pharmacology Interaction Network Database Toward an integrated software platform for systems pharmacology VNP: Interactive Visual Network Pharmacology of Diseases, Targets, and Drugs Self-organization of progress across the century of physics Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour Small world network strategies for studying protein structures and binding.Structural bioinformatics of the interactome.Computational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.Weighted protein residue networks based on joint recurrences between residues Integrating atomistic molecular dynamics simulations, experiments, and network analysis to study protein dynamics: strength in unity.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.An optimal distance cutoff for contact-based Protein Structure Networks using side-chain centers of mass.Molecular interaction networks in the analyses of sequence variation and proteomics data.Updates on drug-target network; facilitating polypharmacology and data integration by growth of DrugBank database.Data Requirements for Model-Based Cancer Prognosis Prediction The development of a universal in silico predictor of protein-protein interactions.Drug repurposing: a better approach for infectious disease drug discovery?Integrating systems biology sources illuminates drug action.

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P2860

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

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Structure and dynamics of mole ...... covery: a comprehensive review

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Computational prediction of human metabolic pathways from the complete human genome

Control centrality and hierarchical structure in complex networks

Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

Protein-protein interactions essentials: key concepts to building and analyzing interactome networks

A dynamic network approach for the study of human phenotypes

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

NetPath: a public resource of curated signal transduction pathways

Initial characterization of the human central proteome

targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis

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