The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models
about
Multiscale simulation of thrombus growth and vessel occlusion triggered by collagen/tissue factor using a data-driven model of combinatorial platelet signalling.Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine.A combined microfluidic-microstencil method for patterning biomolecules and cellsOn-chip recalcification of citrated whole blood using a microfluidic herringbone mixerEx vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technologySystems Analysis of Thrombus Formation.Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis.Global assays of hemostasis.Fluid Mechanics of Blood Clot Formation.Rendering factor Xa zymogen-like as a therapeutic strategy to treat bleeding.Transport physics and biorheology in the setting of hemostasis and thrombosis.Blood flow and mass transfer regulation of coagulation.Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders.Application of microfluidic devices in studies of thrombosis and hemostasis.Computational Study of Thrombus Formation and Clotting Factor Effects under Venous Flow Conditions.Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen-like FXa(I16L).Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow.Recombinant factor VIIa addition to haemophilic blood perfused over collagen/tissue factor can sufficiently bypass the factor IXa/VIIIa defect to rescue fibrin generation.Recombinant factor VIIa enhances platelet deposition from flowing haemophilic blood but requires the contact pathway to promote fibrin deposition.Use of microfluidics to assess the platelet-based control of coagulation.Flow-dependent thrombin and fibrin generation in vitro: opportunities for standardization: communication from SSC of the ISTH.Impact of Tissue Factor Localization on Blood Clot Structure and Resistance under Venous Shear.
P2860
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P2860
The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
The effect of factor VIII defi ...... uidic and computational models
@ast
The effect of factor VIII defi ...... uidic and computational models
@en
The effect of factor VIII defi ...... uidic and computational models
@nl
type
label
The effect of factor VIII defi ...... uidic and computational models
@ast
The effect of factor VIII defi ...... uidic and computational models
@en
The effect of factor VIII defi ...... uidic and computational models
@nl
prefLabel
The effect of factor VIII defi ...... uidic and computational models
@ast
The effect of factor VIII defi ...... uidic and computational models
@en
The effect of factor VIII defi ...... uidic and computational models
@nl
P2093
P2860
P1433
P1476
The effect of factor VIII defi ...... uidic and computational models
@en
P2093
Aaron L Fogelson
Abimbola A Onasoga-Jarvis
Jorge A Di Paola
Karin Leiderman
Keith B Neeves
Marilyn J Manco-Johnson
Michael Wang
P2860
P304
P356
10.1371/JOURNAL.PONE.0078732
P407
P577
2013-01-01T00:00:00Z