Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold
about
Molecular targets for flavivirus drug discoveryStructure and functionality in flavivirus NS-proteins: perspectives for drug designStructural proteomics of dengue virusIllustrating and homology modeling the proteins of the Zika virus.Crystal Structure of the NS3 Protease-Helicase from Dengue VirusThe Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 HelicaseIdentification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput ScreenStructural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput DockingSubstrate inhibition kinetic model for West Nile virus NS2B-NS3 proteaseActivation of the West Nile virus NS3 protease: Molecular dynamics evidence for a conformational selection mechanismNMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 ProteaseCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationFocus on flaviviruses: current and future drug targetsSerotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus FamilyFlexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implicationsLigand-Bound Structures of the Dengue Virus Protease Reveal the Active ConformationDevelopment and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 proteaseStructure of the NS2B-NS3 protease from Zika virus after self-cleavageCrystal structure of unlinked NS2B-NS3 protease from Zika virusEnzymatic analysis of recombinant Japanese encephalitis virus NS2B(H)-NS3pro protease with fluorogenic model peptide substratesIdentification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virusA conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists.Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity.Capturing conformational States in proteins using sparse paramagnetic NMR data.Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 2-{6-[2-(5-phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide scaffold.New binding site conformations of the dengue virus NS3 protease accessed by molecular dynamics simulation.Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigenDesign, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds.Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus.Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.Discovery, synthesis, and in vitro evaluation of West Nile virus protease inhibitors based on the 9,10-dihydro-3H,4aH-1,3,9,10a-tetraazaphenanthren-4-one scaffold.The flavivirus protease as a target for drug discovery.Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 1,3,4,5-tetrasubstituted 1H-pyrrol-2(5H)-one scaffold.Small molecule pan-dengue and West Nile virus NS3 protease inhibitors.Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus.Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.
P2860
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P2860
Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold
description
2007 nî lūn-bûn
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2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
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name
Structural evidence for regula ...... olution of theFlaviviridaefold
@ast
Structural evidence for regula ...... olution of theFlaviviridaefold
@en
Structural evidence for regula ...... olution of theFlaviviridaefold
@nl
type
label
Structural evidence for regula ...... olution of theFlaviviridaefold
@ast
Structural evidence for regula ...... olution of theFlaviviridaefold
@en
Structural evidence for regula ...... olution of theFlaviviridaefold
@nl
prefLabel
Structural evidence for regula ...... olution of theFlaviviridaefold
@ast
Structural evidence for regula ...... olution of theFlaviviridaefold
@en
Structural evidence for regula ...... olution of theFlaviviridaefold
@nl
P2093
P2860
P356
P1433
P1476
Structural evidence for regula ...... olution of theFlaviviridaefold
@en
P2093
Alexander E Aleshin
Robert C Liddington
Sergey A Shiryaev
P2860
P304
P356
10.1110/PS.072753207
P577
2007-05-01T00:00:00Z