Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form - Wikidata - wikimedia - TriplyDB

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

http://www.wikidata.org/entity/Q27484186

about

NS3 protease from hepatitis C virus: biophysical studies on an intrinsically disordered protein domain Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis viruses Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli.Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines.Virus-specific cofactor requirement and chimeric hepatitis C virus/GB virus B nonstructural protein 3 Isolation and characterization of monoclonal antibodies that inhibit hepatitis C virus NS3 protease Generation and characterization of a hepatitis C virus NS3 protease-dependent bovine viral diarrhea virus Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins Topology of the Membrane-Associated Hepatitis C Virus Protein NS4B Curation of viral genomes: challenges, applications and the way forward The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication Studying Hepatitis C Virus: Making the Best of a Bad Virus Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease A novel recombinant single-chain hepatitis C virus ns3-ns4a protein with improved helicase activity Conformational changes in the NS3 protease from hepatitis C virus strain Bk monitored by limited proteolysis and mass spectrometry Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold Crystal Structure of the NS3 Protease-Helicase from Dengue Virus Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition Doc of Prophage P1 Is Inhibited by Its Antitoxin Partner Phd through Fold Complementation Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications The design and synthesis of potent inhibitors of hepatitis C virus NS3-4A proteinase Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing Comparative molecular dynamics simulation of Hepatitis C Virus NS3/4A protease (Genotypes 1b, 3a and 4b) predicts conformational instability of the catalytic triad in drug resistant strains Phylogenetic and 2D/3D Analysis of HCV 1a NS4A Gene/Protein in Pakistani Isolates.The herpesvirus proteases as targets for antiviral chemotherapy.Inhibiting viral proteases: challenges and opportunities.New binding site conformations of the dengue virus NS3 protease accessed by molecular dynamics simulation.Macrocyclic inhibitors of HCV NS3 protease.Perspectives for the treatment of infections with Flaviviridae.Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery.

P2860

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P2860

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

http://www.wikidata.org/entity/Q27484186

description

1998 nî lūn-bûn

@nan

1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի ապրիլին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

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Complex of NS3 protease and NS ...... re in a hexagonal crystal form

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Complex of NS3 protease and NS ...... re in a hexagonal crystal form

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Complex of NS3 protease and NS ...... re in a hexagonal crystal form

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Complex of NS3 protease and NS ...... re in a hexagonal crystal form

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Complex of NS3 protease and NS ...... re in a hexagonal crystal form

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Complex of NS3 protease and NS ...... re in a hexagonal crystal form

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Protein Science

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Complex of NS3 protease and NS ...... re in a hexagonal crystal form

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P2093

Chen Z

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Cole JL

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Kuo LC

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Li Y

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Munshi S

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Sardana M

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Sardana V

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Steinkuehler C

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Tomei L

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Yan Y

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P2860

Kinetic and structural analyses of hepatitis C virus polyprotein processing

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing

A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro

Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease

Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics

Expression and identification of hepatitis C virus polyprotein cleavage products

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus

P304

837-847

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scholarly article

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10.1002/PRO.5560070402

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4

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7

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Raffaele De Francesco

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1998-04-01T00:00:00Z

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13711389

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9568891

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2143993

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