The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis
about
Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequenceImmune signaling by RIG-I-like receptorsUXT plays dual opposing roles on SARM-induced apoptosisThe interferon-stimulated gene IFITM3 restricts West Nile virus infection and pathogenesisWest Nile Virus: biology, transmission, and human infectionInsights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carpInterferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infectionZika virus disrupts molecular fingerprinting of human neurospheresSarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphologyInflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitisThe interferon-inducible gene viperin restricts West Nile virus pathogenesisNLRP3 Inflammasome in Neurological Diseases, from Functions to TherapiesSARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected.Computational modeling of cytokine signaling in microglia.2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivoPro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal deathHistone methylation analysis and pathway predictions in chickens after MDV infection.Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential.The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.TNF-α acts as an immunoregulator in the mouse brain by reducing the incidence of severe disease following Japanese encephalitis virus infectionToll-like receptor signaling in neural plasticity and disease.Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neuronsHm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leechT-cell death following immune activation is mediated by mitochondria-localized SARM.Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.Toll-like receptor 7 suppresses virus replication in neurons but does not affect viral pathogenesis in a mouse model of Langat virus infection.A role for Ifit2 in restricting West Nile virus infection in the brainThe role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells.Sarm1-mediated axon degeneration requires both SAM and TIR interactionsEncephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response.MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia.Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters.Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator.Resveratrol inhibits the TRIF-dependent pathway by upregulating sterile alpha and armadillo motif protein, contributing to anti-inflammatory effects after respiratory syncytial virus infection.Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3KPathogen recognition receptors: ligands and signaling pathways by Toll-like receptors.
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P2860
The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@ast
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@en
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@nl
type
label
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@ast
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@en
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@nl
prefLabel
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@ast
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@en
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@nl
P2860
P50
P921
P3181
P356
P1433
P1476
The Immune Adaptor Molecule SA ...... s West Nile Virus Pathogenesis
@en
P2093
Anja Fuchs
Melanie A Samuel
P2860
P304
P3181
P356
10.1128/JVI.00836-09
P577
2009-09-01T00:00:00Z