Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
about
The genome of the social amoeba Dictyostelium discoideumStructural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteinsIdentification and functional characterization of an Src homology domain 3 domain-binding site on CblMolecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinaseStructural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substratesFunctional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transitionRegulatory and signaling properties of the Vav familyStructural basis for autoinhibition and phosphorylation-dependent activation of c-CblRegulation of protein tyrosine kinase signaling by substrate degradation during brain developmentSLAP, a dimeric adapter protein, plays a functional role in T cell receptor signalingCbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cellsRING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesStructure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR DegradationAdditional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB DomainAutoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-bThe paradox of conformational constraint in the design of Cbl(TKB)-binding peptidesEssentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cellsThe autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding proteinThe involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activationEvidence for direct interaction between Sprouty and CblThe adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interactionInteraction domains: from simple binding events to complex cellular behaviorHematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytesRegulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptorThe language of SH2 domain interactions defines phosphotyrosine-mediated signal transductionMutant Cbl proteins as oncogenic drivers in myeloproliferative disordersThe non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin GTarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylationThe Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode.Combining multiple structure and sequence alignments to improve sequence detection and alignment: application to the SH2 domains of Janus kinases.Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding.Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis.
P2860
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P2860
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@ast
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@en
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@nl
type
label
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@ast
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@en
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@nl
prefLabel
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@ast
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@en
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@nl
P2093
P2860
P356
P1433
P1476
Structure of the amino-termina ...... binding site on ZAP-70 kinase
@en
P2093
S J Burakoff
S Sawasdikosol
P2860
P2888
P356
10.1038/18050
P407
P577
1999-03-04T00:00:00Z
P5875
P6179
1028294143