The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. - Wikidata - wikimedia - TriplyDB

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.

http://www.wikidata.org/entity/Q30175273

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Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation Negative regulation of Lck by Cbl ubiquitin ligase c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases Ruk is ubiquitinated but not degraded by the proteasome Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2 The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.Regulation of the Src family kinase Lck by Hsp90 and ubiquitination The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice c-Cbl-mediated regulation of LAT-nucleated signaling complexes Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.Roles of E3 ubiquitin ligases in cell adhesion and migration.Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex.Myristoylation and membrane binding regulate c-Src stability and kinase activity Cbl: many adaptations to regulate protein tyrosine kinases.Beyond the RING: CBL proteins as multivalent adapters.The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases.Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A Constitutive endocytosis and degradation of the pre-T cell receptor.Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.Vascular smooth muscle cell motility is mediated by a physical and functional interaction of Ca2+/calmodulin-dependent protein kinase IIδ2 and Fyn.Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunity The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling.An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.Cbl family proteins: balancing FcεRI-mediated mast cell and basophil activation.E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation.

P2860

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P2860

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.

http://www.wikidata.org/entity/Q30175273

description

2000 nî lūn-bûn

@nan

2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի փետրվարին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

The Cbl proto-oncogene product ...... by enhancing its degradation.

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The Cbl proto-oncogene product ...... by enhancing its degradation.

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The Cbl proto-oncogene product ...... by enhancing its degradation.

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The Cbl proto-oncogene product ...... by enhancing its degradation.

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The Cbl proto-oncogene product ...... by enhancing its degradation.

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MCB.20.3.851-867.2000

P1433

Molecular and Cellular Biology

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The Cbl proto-oncogene product ...... by enhancing its degradation.

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P2093

C B Thien

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C E Andoniou

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D D Bowtell

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H Band

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M L Lupher

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N L Lill

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R M Scaife

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S Ota

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W Y Langdon

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P2860

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

Three-dimensional structure of the tyrosine kinase c-Src

Crystal structure of the Src family tyrosine kinase Hck

High-efficiency transformation of mammalian cells by plasmid DNA

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851-867

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10.1128/MCB.20.3.851-867.2000

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3

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12685391

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10629042

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85202

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