The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains
about
Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbetaCooperative binding of DNA and CBFbeta to the Runt domain of the CBFalpha studied via MD simulations.Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancerMutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitIdentification of the regions involved in DNA binding by the mouse PEBP2alpha protein.Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.Overview of protein structural and functional folds.CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.Deuterated protein folds obtained directly from unassigned nuclear overhauser effect data.Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingOncogenic potential of the RUNX gene family: 'overview'.Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healingRUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Automated protein fold determination using a minimal NMR constraint strategy.Site-specific evolutionary rates in proteins are better modeled as non-independent and strictly relative.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Evolution of the JAK-STAT pathway.Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor.Genetic regulation of the RUNX transcription factor family has antitumor effectsOct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-caseinEnergetic contribution of residues in the Runx1 Runt domain to DNA binding.Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells.Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.Genetic compensation of RUNX family transcription factors in leukemia
P2860
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P2860
The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@ast
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@en
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@nl
type
label
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@ast
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@en
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@nl
prefLabel
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@ast
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@en
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@nl
P2093
P1433
P1476
The Ig fold of the core bindin ...... ed Ig-fold DNA-binding domains
@en
P2093
F Abildgaard
J H Bushweller
M J Berardi
P304
P356
10.1016/S0969-2126(00)80058-1
P577
1999-10-15T00:00:00Z