Energetic contribution of residues in the Runx1 Runt domain to DNA binding. - Wikidata - wikimedia - TriplyDB

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

http://www.wikidata.org/entity/Q44478788

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Cooperative binding of DNA and CBFbeta to the Runt domain of the CBFalpha studied via MD simulations.Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks.Genome wide molecular analysis of minimally differentiated acute myeloid leukemia.The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation.The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives.ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1.Characterization of critical interactions between Ndt80 and MSE DNA defining a novel family of Ig-fold transcription factors.RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia.

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Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

http://www.wikidata.org/entity/Q44478788

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh

2003年學術文章

@zh-hant

name

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

@en

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

@nl

type

label

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

@en

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

@nl

prefLabel

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

@en

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

@nl

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P1433

Journal of Biological Chemistry

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Energetic contribution of residues in the Runx1 Runt domain to DNA binding

@en

P2093

Alan J Warren

http://www.w3.org/2001/XMLSchema#string

Christina J Matheny

http://www.w3.org/2001/XMLSchema#string

Jiangli Yan

http://www.w3.org/2001/XMLSchema#string

Nancy A Speck

http://www.w3.org/2001/XMLSchema#string

Takeshi Corpora

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Zhe Li

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P2860

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

Thermodynamic stability of wild-type and mutant p53 core domain

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

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33088-33096

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scholarly article

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10.1074/JBC.M303973200

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35

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278

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Jerónimo Bravo

John H Bushweller

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2003-06-13T00:00:00Z

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10707067

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12807882

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