Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
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Cooperative binding of DNA and CBFbeta to the Runt domain of the CBFalpha studied via MD simulations.Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitStructure and Biophysics of CBFβ/RUNX and Its Translocation Products.CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatmentPRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potentialRunx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healingCombined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks.Genome wide molecular analysis of minimally differentiated acute myeloid leukemia.The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation.The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives.ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1.Characterization of critical interactions between Ndt80 and MSE DNA defining a novel family of Ig-fold transcription factors.RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia.
P2860
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P2860
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
@en
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
@nl
type
label
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
@en
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
@nl
prefLabel
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
@en
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
@nl
P2093
P2860
P356
P1476
Energetic contribution of residues in the Runx1 Runt domain to DNA binding
@en
P2093
Alan J Warren
Christina J Matheny
Jiangli Yan
Nancy A Speck
Takeshi Corpora
P2860
P304
33088-33096
P356
10.1074/JBC.M303973200
P407
P577
2003-06-13T00:00:00Z