Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.
about
Cooperative binding of DNA and CBFbeta to the Runt domain of the CBFalpha studied via MD simulations.Mutations in the RUNX2 gene in patients with cleidocranial dysplasiaMutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitStructure and Biophysics of CBFβ/RUNX and Its Translocation Products.PI(2)PE: A Suite of Web Servers for Predictions Ranging From Protein Structure to Binding Kinetics.CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.Core-binding factor influences the disease specificity of Moloney murine leukemia virusDistinct contributions of conserved modules to Runt transcription factor activityCore-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation.Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healingCommitment to the osteoblast lineage is not required for RANKL gene expression.CBFß and HIV Infection.HIV type 1 viral infectivity factor and the RUNX transcription factors interact with core binding factor β on genetically distinct surfaces.RUN-CBFbeta interaction in C. elegans: computational prediction and experimental verification.Energetic contribution of residues in the Runx1 Runt domain to DNA binding.Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and myelodysplastic syndrome.Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium.
P2860
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P2860
Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年學術文章
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name
Biophysical characterization o ...... pha and beta subunits and DNA.
@en
Biophysical characterization o ...... pha and beta subunits and DNA.
@nl
type
label
Biophysical characterization o ...... pha and beta subunits and DNA.
@en
Biophysical characterization o ...... pha and beta subunits and DNA.
@nl
prefLabel
Biophysical characterization o ...... pha and beta subunits and DNA.
@en
Biophysical characterization o ...... pha and beta subunits and DNA.
@nl
P2093
P2860
P1433
P1476
Biophysical characterization o ...... pha and beta subunits and DNA.
@en
P2093
Bushweller JH
Hartman KL
P2860
P304
P356
10.1016/S0014-5793(00)01312-0
P407
P577
2000-03-01T00:00:00Z