The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
about
A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.Caspases: pharmacological manipulation of cell deathCrystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residueDimer formation drives the activation of the cell death protease caspase 9Structural basis for the activation of human procaspase-7Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathwayCrystal structure of an invertebrate caspasePlasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysisStructural basis for executioner caspase recognition of P5 position in substratesL2′ loop is critical for caspase-7 active site formationThe crystal structure of caspase-6, a selective effector of axonal degenerationSubstrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6A designed redox-controlled caspaseMolecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationCrystal structure of a Trypanosoma brucei metacaspaseStructural asymmetry of procaspase-7 bound to a specific inhibitorPhage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafishCaspases: opening the boxes and interpreting the arrowsProteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificityAlternative programs of cell death in developing retinal tissueMolecular mechanisms of caspase regulation during apoptosisOverview of protein structural and functional folds.Discovery of an allosteric site in the caspasesInvestigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactionsSynthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivoStructural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO.Small-molecule activators of a proenzyme.Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival.Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine.A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly.Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Different apoptotic effects of [Pt(O,O'-acac)(γ-acac)(DMS)] and cisplatin on normal and cancerous human epithelial breast cells in primary culturePeptides in apoptosis research.MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activityAn uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3.Turning on caspases with genetics and small moleculesChemical-induced apoptosis: formation of the Apaf-1 apoptosome.Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injurySmall Molecule Active Site Directed Tools for Studying Human Caspases
P2860
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P2860
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The structures of caspases-1, ...... rate and inhibitor selectivity
@ast
The structures of caspases-1, ...... rate and inhibitor selectivity
@en
The structures of caspases-1, ...... rate and inhibitor selectivity
@nl
type
label
The structures of caspases-1, ...... rate and inhibitor selectivity
@ast
The structures of caspases-1, ...... rate and inhibitor selectivity
@en
The structures of caspases-1, ...... rate and inhibitor selectivity
@nl
prefLabel
The structures of caspases-1, ...... rate and inhibitor selectivity
@ast
The structures of caspases-1, ...... rate and inhibitor selectivity
@en
The structures of caspases-1, ...... rate and inhibitor selectivity
@nl
P2093
P1476
The structures of caspases-1, ...... rate and inhibitor selectivity
@en
P2093
J Sintchak
K P Wilson
P S Charifson
S P Chambers
P304
P356
10.1016/S1074-5521(00)00123-X
P577
2000-06-01T00:00:00Z