An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3.
about
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosisAllosteric modulation of caspase 3 through mutagenesisPhage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafishTunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selectionPAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibitionProcaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compoundDual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activitySmall-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse ChemotherapeuticsLarge-scale preparation of active caspase-3 in E. coli by designing its thrombin-activatable precursorsQuantitative analysis of pathways controlling extrinsic apoptosis in single cellsA bifunctional allosteric site in the dimer interface of procaspase-3Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesisA short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly.A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Modifying caspase-3 activity by altering allosteric networks.Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker.Mutations in the procaspase-3 dimer interface affect the activity of the zymogen.Reassembly of active caspase-3 is facilitated by the propeptide.Targeting cell death in tumors by activating caspases.Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3.Photofrin binds to procaspase-3 and mediates photodynamic treatment-triggered methionine oxidation and inactivation of procaspase-3.pH effects on the stability and dimerization of procaspase-3.Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma.Death by caspase dimerization.Redesigning the procaspase-8 dimer interface for improved dimerization.Folding and assembly kinetics of procaspase-3.Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3.Practical approaches to protein folding and assembly: spectroscopic strategies in thermodynamics and kinetics.Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients.Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach.Modifications to a common phosphorylation network provide individualized control in caspases.Modulation of procaspase-7 self-activation by PEST amino acid residues of the N-terminal prodomain and intersubunit linker.Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
P2860
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P2860
An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
An uncleavable procaspase-3 mu ...... r to that of mature caspase-3.
@ast
An uncleavable procaspase-3 mu ...... r to that of mature caspase-3.
@en
type
label
An uncleavable procaspase-3 mu ...... r to that of mature caspase-3.
@ast
An uncleavable procaspase-3 mu ...... r to that of mature caspase-3.
@en
prefLabel
An uncleavable procaspase-3 mu ...... r to that of mature caspase-3.
@ast
An uncleavable procaspase-3 mu ...... r to that of mature caspase-3.
@en
P2093
P2860
P356
P1433
P1476
An uncleavable procaspase-3 mu ...... r to that of mature caspase-3.
@en
P2093
A Clay Clark
Brett Feeney
Cristina Pop
Kakoli Bose
P2860
P304
12298-12310
P356
10.1021/BI034998X
P407
P577
2003-10-01T00:00:00Z