A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase
about
An essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coliFlexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug designCrystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGTHow to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylaseInvestigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as InhibitorFrom lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersReplacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)Decoys for dockingDocking screens: right for the right reasons?Docking Screens for Novel Ligands Conferring New Biology.Virtual screening of chemical libraries.Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionThe role of aspartic acid 143 in E. coli tRNA-guanine transglycosylase: insights from mutagenesis studies and computational modeling.The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.Systematic placement of structural water molecules for improved scoring of protein-ligand interactionsStructural characterization of the late competence protein ComFB from Bacillus subtilis.Structure and function of noncanonical nucleobases.Molecular recognition in chemical and biological systems.A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase.Evidence of a sequestered imine intermediate during reduction of nitrile to amine by the nitrile reductase QueF from Escherichia coli.An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT).Computational Methods to Support Fragment-based Drug Discovery
P2860
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P2860
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@ast
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@en
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@nl
type
label
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@ast
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@en
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@nl
prefLabel
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@ast
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@en
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@nl
P2093
P356
P1476
A new target for shigellosis: ...... tRNA-guanine transglycosylase
@en
P2093
Goodenough-Lashua DM
P304
P356
10.1006/JMBI.2000.4256
P407
P577
2001-02-01T00:00:00Z