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Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD proteinMutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activityCrystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilinA new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylaseCrystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesisVirtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysisFlexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug designAn integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interactionSynthesis of 5-Hydroxyectoine from Ectoine: Crystal Structure of the Non-Heme Iron(II) and 2-Oxoglutarate-Dependent Dioxygenase EctDHigh resolution crystal structure of Clostridium propionicum β-alanyl-CoA:ammonia lyase, a new member of the "hot dog fold" protein superfamilyWhat Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme TgtMutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophileSoaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionMechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism.Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme.Screening orthologs as an important variable in crystallization: preliminary X-ray diffraction studies of the tRNA-modifying enzyme S-adenosyl-methionine:tRNA ribosyl transferase/isomerase.Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening.Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster.Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine TransglycosylasePurification, crystallization, and preliminary x-ray diffraction studies of tRNA-guanine transglycosylase from Zymomonas mobilisSerine 90 is required for enzymic activity by tRNA-guanine transglycosylase from Escherichia coliOverproduction, purification, crystallization and preliminary x-ray diffraction studies of the human spliceosomal protein U5-15kDCrystallization and preliminary crystallographic studies of Sfp: a phosphopantetheinyl transferase of modular peptide synthetasesA crystallization screen based on alternative polymeric precipitants
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description
researcher
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wetenschapper
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հետազոտող
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name
K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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K Reuter
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P106
P31
P496
0000-0003-3673-7971