A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase.
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First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingGlutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquitoEosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum.Folate metabolism as a source of molecular targets for antimalarials.Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis.Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductaseFolate metabolic pathways in LeishmaniaUnderstanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR.Efficacy of eosin B as a new antimalarial drug in a murine model.Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
P2860
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P2860
A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase.
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name
A molecular docking strategy i ...... thase-dihydrofolate reductase.
@en
A molecular docking strategy i ...... thase-dihydrofolate reductase.
@nl
type
label
A molecular docking strategy i ...... thase-dihydrofolate reductase.
@en
A molecular docking strategy i ...... thase-dihydrofolate reductase.
@nl
prefLabel
A molecular docking strategy i ...... thase-dihydrofolate reductase.
@en
A molecular docking strategy i ...... thase-dihydrofolate reductase.
@nl
P2093
P2860
P50
P356
P1476
A molecular docking strategy i ...... thase-dihydrofolate reductase.
@en
P2093
Antonia Dow
Brian K Shoichet
Chloé E Atreya
Eric F Johnson
Isabelle Coppens
Karen S Anderson
Kristen M Massimine
Valeska Stempliuk
P2860
P304
14092-14100
P356
10.1074/JBC.M212690200
P407
P577
2003-01-29T00:00:00Z