Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain
about
Allosteric Inhibition of Human Immunodeficiency Virus IntegraseCrystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding siteMultimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase InhibitorsNew Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of ActionA new class of multimerization selective inhibitors of HIV-1 integraseDiscovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1A historical sketch of the discovery and development of HIV-1 integrase inhibitorsNon-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cellsStructural Basis for Inhibitor-Induced Aggregation of HIV IntegraseRetroviral DNA IntegrationIdentification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.Solution conformation and dynamics of the HIV-1 integrase core domain.Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistancePhage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.Discovery of a small-molecule HIV-1 integrase inhibitor-binding siteAllosteric inhibitor development targeting HIV-1 integrase.FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.Host Factors in Retroviral Integration and the Selection of Integration Target Sites.HIV DNA integration.C-Terminal Domain of Integrase Binds between the Two Active SitesStructural biology of retroviral DNA integration.Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.Integrase, LEDGF/p75 and HIV replication.In search of small molecules blocking interactions between HIV proteins and intracellular cofactors.Piecing together the structure of retroviral integrase, an important target in AIDS therapyAffinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional InsightsHIV-1 integrase multimerization as a therapeutic target.Retroviral integrase protein and intasome nucleoprotein complex structures.The conformational feasibility for the formation of reaching dimer in ASV and HIV integrase: a molecular dynamics study.Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.Cellular cofactors of lentiviral integrase: from target validation to drug discovery.
P2860
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P2860
Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of a small-mole ...... HIV integrase catalytic domain
@ast
Identification of a small-mole ...... HIV integrase catalytic domain
@en
Identification of a small-mole ...... HIV integrase catalytic domain
@nl
type
label
Identification of a small-mole ...... HIV integrase catalytic domain
@ast
Identification of a small-mole ...... HIV integrase catalytic domain
@en
Identification of a small-mole ...... HIV integrase catalytic domain
@nl
prefLabel
Identification of a small-mole ...... HIV integrase catalytic domain
@ast
Identification of a small-mole ...... HIV integrase catalytic domain
@en
Identification of a small-mole ...... HIV integrase catalytic domain
@nl
P2093
P3181
P1476
Identification of a small-mole ...... HIV integrase catalytic domain
@en
P2093
F D Bushman
J Greenwald
W Kwiatkowski
P304
P3181
P356
10.1107/S0907444901001652
P50
P577
2001-04-01T00:00:00Z