Discovery of a small-molecule HIV-1 integrase inhibitor-binding site - Wikidata - wikimedia - TriplyDB

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

http://www.wikidata.org/entity/Q34772524

about

Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action A historical sketch of the discovery and development of HIV-1 integrase inhibitors A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics.An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.HIV-1 IN inhibitors: 2010 update and perspectives Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions.Allosteric inhibitor development targeting HIV-1 integrase.FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.Hybrid quantum mechanical/molecular mechanical molecular dynamics simulations of HIV-1 integrase/inhibitor complexes.Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.Integrase, LEDGF/p75 and HIV replication.In search of small molecules blocking interactions between HIV proteins and intracellular cofactors.Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.Mass spectrometry-based structural proteomics."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.HIV-1 integrase multimerization as a therapeutic target.3-Phenylcoumarins as inhibitors of HIV-1 replication.Inhibition of dengue virus polymerase by blocking of the RNA tunnel Inhibiting the HIV integration process: past, present, and the future.Target Identification by Diazirine Photo-Cross-linking and Click Chemistry.Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides.Examining the mechanism of action of a kinesin inhibitor using stable isotope labeled inhibitors for cross-linking (SILIC).Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition.Computer-aided design and discovery of protein-protein interaction inhibitors as agents for anti-HIV therapy.Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry.Defining the DNA substrate binding sites on HIV-1 integrase.Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles.Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors.Insight into the inhibitory mechanism and binding mode between D77 and HIV-1 integrase by molecular modeling methods.Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity.

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P2860

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

http://www.wikidata.org/entity/Q34772524

description

2006 nî lūn-bûn

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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2006 թվականի հունիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

@ast

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

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type

label

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

@en

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

@nl

prefLabel

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

@ast

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

@en

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

@en

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Christoph H Borchers

http://www.w3.org/2001/XMLSchema#string

Laith Q Al-Mawsawi

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Myriam Witvrouw

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Nouri Neamati

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Raveendra Dayam

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Terrence R Burke

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Valery Fikkert

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P2860

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.

Atomic structure of the RuvC resolvase: a holliday junction-specific endonuclease from E. coli

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

Identification of a nucleotide binding site in HIV-1 integrase

Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.

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103

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16785440

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