Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins
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Diversity of Eukaryotic Translational Initiation Factor eIF4E in Protists7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activityLarge-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complexEukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5' capStructural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1Functional analysis of mRNA scavenger decapping enzymes.The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationStructural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton proteinWeak binding affinity of human 4EHP for mRNA cap analogsDBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradationFunctional characterization of a 48 kDa Trypanosoma brucei cap 2 RNA methyltransferaseAnalysis of Flavivirus NS5 Methyltransferase Cap BindingThe Structure of Eukaryotic Translation Initiation Factor-4E from Wheat Reveals a Novel Disulfide BondThe structural basis for cap binding by influenza virus polymerase subunit PB2Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1Structural Insights into Parasite eIF4E Binding Specificity for m7G and m2,2,7G mRNA CapsStructure-Based Mutational Analysis of eIF4E in Relation to sbm1 Resistance to Pea Seed-Borne Mosaic Virus in PeaCrystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repressionStructural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiationStructural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4EeIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognitionStructure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4GNew affinity resin for purification of cap-binding proteinsQuantitative studies of mRNA recruitment to the eukaryotic ribosomeNontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translationNew hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stressChemical synthesis and binding activity of the trypanosomatid cap-4 structure.Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMPTranslation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform.Cap analog substrates reveal three clades of cap guanine-N2 methyltransferases with distinct methyl acceptor specificities.Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognitionApplications of Phosphate Modification and Labeling to Study (m)RNA Caps.Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA capDynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.3' cap-independent translation enhancers of plant viruses.Hantavirus nucleocapsid protein has distinct m7G cap- and RNA-binding sites.Biosensor-based small molecule fragment screening with biolayer interferometry.eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma bruceiTowards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog.
P2860
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P2860
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins
description
2002 nî lūn-bûn
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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@ast
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@en
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@nl
type
label
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@ast
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@en
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@nl
prefLabel
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@ast
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@en
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@nl
P2093
P50
P3181
P1476
Biophysical studies of eIF4E c ...... s of eIF4G and 4E-BP1 proteins
@en
P2093
Aleksandra Wyslouch-Cieszynska
Janusz Stepinski
Joseph Marcotrigiano
Marzena Jankowska-Anyszka
Ryszard Stolarski
P304
P3181
P356
10.1016/S0022-2836(02)00328-5
P407
P50
P577
2002-06-07T00:00:00Z