Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation - Wikidata - wikimedia - TriplyDB

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

http://www.wikidata.org/entity/Q27640571

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Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7 Molecular mechanisms underlying RB protein function Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor Crystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein Architecture Protein crystallography with a micrometre-sized synchrotron-radiation beam Crystal structure of the unliganded retinoblastoma protein pocket domain Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control Molecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequences SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation RB regulates pancreas development by stabilizing Pdx1 A comparative study of Whi5 and retinoblastoma proteins: from sequence and structure analysis to intracellular networks.A 7μm mini-beam improves diffraction data from small or imperfect crystals of macromolecules Cell size checkpoint control by the retinoblastoma tumor suppressor pathway Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain.Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding Reconstruction from limited single-particle diffraction data via simultaneous determination of state, orientation, intensity, and phase Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor.Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein Clefts, grooves, and (small) pockets: the structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled.Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein Structural and functional characterization of the acidic region from the RIZ tumor suppressor.Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection.Structural mechanisms of DREAM complex assembly and regulation.Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins.Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression RB1, development, and cancer.Regulation of the retinoblastoma proteins by the human herpesviruses.Mini-beam collimator enables microcrystallography experiments on standard beamlines A novel motif in geminivirus replication proteins interacts with the plant retinoblastoma-related protein.Somatic alterations in brain tumors.Identification and modulation of a caveolae-dependent signal pathway that regulates plasminogen activator inhibitor-1 in insulin-resistant adipocytes Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery.Deciphering the retinoblastoma protein phosphorylation code.MDMX exerts its oncogenic activity via suppression of retinoblastoma protein.

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P2860

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

http://www.wikidata.org/entity/Q27640571

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2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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Proceedings of the National Academy of Sciences of the United States of America

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Crystal structure of the retin ...... ecular basis of its regulation

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Adrienne Clements

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Bing Xiao

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Cristina Broceño

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James Spencer

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Manfred Burghammer

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Nadeem Ali-Khan

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Sibylle Mittnacht

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Steven J Gamblin

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P2860

Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

Overexpression of pRB in human pancreatic carcinoma cells: function in chemotherapy-induced apoptosis.

The retinoblastoma protein and cell cycle control

The CCP4 suite: programs for protein crystallography

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

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Ronen Marmorstein

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10889122

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protein structure

crystal structure

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151346

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