Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis

Item
http://www.wikidata.org/entity/Q27640724
AffinDB: a freely accessible database of affinities for protein-ligand complexes from the PDBAn essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coliFlexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug designGlutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic StudiesA Structure-Based Approach to Ligand Discovery for 2 C -Methyl- d -erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy †Docking for fragment inhibitors of AmpC  -lactamaseCombining docking with pharmacophore filtering for improved virtual screeningIdentification of Plasmodium falciparum apicoplast-targeted tRNA-guanine transglycosylase and its potential inhibitors using comparative genomics, molecular modelling, docking and simulation studiesAnalysis of structure-based virtual screening studies and characterization of identified active compounds.The role of aspartic acid 143 in E. coli tRNA-guanine transglycosylase: insights from mutagenesis studies and computational modeling.Structure-based design of small-molecule protein-protein interaction modulators: the story so far.Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism.Ligand discovery and virtual screening using the program LIDAEUS.An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT).
P2860

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis

Item
http://www.wikidata.org/entity/Q27640724
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2003 nî lūn-bûn
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Virtual screening for submicro ...... by crystal structure analysis
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Virtual screening for submicro ...... by crystal structure analysis
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Virtual screening for submicro ...... by crystal structure analysis
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label
Virtual screening for submicro ...... by crystal structure analysis
@ast
Virtual screening for submicro ...... by crystal structure analysis
@en
Virtual screening for submicro ...... by crystal structure analysis
@nl
prefLabel
Virtual screening for submicro ...... by crystal structure analysis
@ast
Virtual screening for submicro ...... by crystal structure analysis
@en
Virtual screening for submicro ...... by crystal structure analysis
@nl
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Virtual screening for submicro ...... by crystal structure analysis
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921