Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme
about
A novel role for MAPKAPK2 in morphogenesis during zebrafish developmentCrystal structure of the p38 alpha-MAPKAP kinase 2 heterodimerStructure of the human protein kinase MPSK1 reveals an atypical activation loop architectureSpecificity of linear motifs that bind to a common mitogen-activated protein kinase docking grooveMolecular basis of MAPK-activated protein kinase 2:p38 assemblyStructural and Functional Characterization of the Human Protein Kinase ASK1High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligandThe Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1Structure of the β-form of human MK2 in complex with the non-selective kinase inhibitor TEI-L03090Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitorScaffolding by ERK3 regulates MK5 in developmentRational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study.Phosphorylation and function of the kaposin B direct repeats of Kaposi's sarcoma-associated herpesvirus.Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical TrialsReconstitution of modular PDK1 functions on trans-splicing of the regulatory PH and catalytic kinase domainsp38 pathway kinases as anti-inflammatory drug targets.p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression.Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5.Low-molecular-weight MK2 inhibitors: a tough nut to crack!A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.Identifying protein construct variants with increased crystallization propensity--a case study.Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.Computational insight into p21-activated kinase 4 inhibition: a combined ligand- and structure-based approach.Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions.Understanding the molecular basis of MK2-p38α signaling complex assembly: insights into protein-protein interaction by molecular dynamics and free energy studies.
P2860
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P2860
Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@ast
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@en
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@nl
type
label
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@ast
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@en
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@nl
prefLabel
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@ast
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@en
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@nl
P2093
P1433
P1476
Catalytically active MAP KAP k ...... with the autoinhibited enzyme
@en
P2093
Chu-Lai Hsiao
Elizabeth Federico
Jasbir Seehra
Jean-Baptiste Telliez
Karl Malakian
Kathryn W Underwood
Kevin D Parris
Kristine Svenson
Lidia Mosyak
Lih-Ling Lin
P304
P356
10.1016/S0969-2126(03)00092-3
P577
2003-06-01T00:00:00Z