Low-molecular-weight MK2 inhibitors: a tough nut to crack! - Wikidata - wikimedia - TriplyDB

Low-molecular-weight MK2 inhibitors: a tough nut to crack!

Low-molecular-weight MK2 inhibitors: a tough nut to crack!

http://www.wikidata.org/entity/Q37855881

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Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials System-based drug discovery within the human kinome.Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease.Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells.The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome.Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure.Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells.

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Low-molecular-weight MK2 inhibitors: a tough nut to crack!

http://www.wikidata.org/entity/Q37855881

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Low-molecular-weight MK2 inhibitors: a tough nut to crack!

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Low-molecular-weight MK2 inhibitors: a tough nut to crack!

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Low-molecular-weight MK2 inhibitors: a tough nut to crack!

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Low-molecular-weight MK2 inhibitors: a tough nut to crack!

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Low-molecular-weight MK2 inhibitors: a tough nut to crack!

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Low-molecular-weight MK2 inhibitors: a tough nut to crack!

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Future Medicinal Chemistry

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Low-molecular-weight MK2 inhibitors: a tough nut to crack!

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P2093

Christine Huppertz

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P2860

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export

Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme

Molecular basis of MAPK-activated protein kinase 2:p38 assembly

Structural basis for a high affinity inhibitor bound to protein kinase MK2

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

The discovery of carboline analogs as potent MAPKAP-K2 inhibitors

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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1243-1257

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scholarly article

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10.4155/FMC.09.98

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7

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1

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Achim Schlapbach

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2009-10-01T00:00:00Z

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50807201

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21426101

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