Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
about
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilizationA distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking grooveActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesDruggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe MoleculesMolecular basis of MAPK-activated protein kinase 2:p38 assemblyHigh-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligandThe Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1Protein–peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinaseExploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTERCo-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailIdentification of a Novel Inhibitory Allosteric Site in p38αThe diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitorRational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study.A model of a MAPK•substrate complex in an active conformation: a computational and experimental approachMK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stressSelective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifsp38α MAPK is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation.Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trialsp38 pathway kinases as anti-inflammatory drug targets.Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.Preventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress.Label transfer reagents to probe p38 MAPK binding partnersStructural basis for the regulation of the mitogen-activated protein (MAP) kinase p38α by the dual specificity phosphatase 16 MAP kinase binding domain in solutionKinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression.Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinaseLow-molecular-weight MK2 inhibitors: a tough nut to crack!Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response.Molecular basis of MAP kinase regulation.Revisiting protein kinase-substrate interactions: Toward therapeutic development.Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38α.Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity.Mitogen-activated protein kinase signaling and its association with oxidative stress and apoptosis in lead-exposed hepatocytes.Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes.Active p38 MAPK phosphorylates MAPKAPK2 or 3
P2860
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P2860
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@ast
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@en
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@en-gb
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@nl
type
label
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@ast
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@en
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@en-gb
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@nl
prefLabel
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@ast
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@en
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@en-gb
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@nl
P2093
P2860
P356
P1476
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
@en
P2093
Christopher Lepre
Ernst ter Haar
Prakash Prabakhar
Prakash Prabhakar
P2860
P304
P356
10.1074/JBC.M611165200
P407
P577
2007-03-30T00:00:00Z