Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate
about
Crystal structure of the catalytic domain of RluD, the only rRNA pseudouridine synthase required for normal growth of Escherichia coliStructure of tRNA Dimethylallyltransferase: RNA Modification through a ChannelGlutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic StudiesCrystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGTSnapshots of Dynamics in Synthesizing N 6 -Isopentenyladenosine at the tRNA AnticodonTertiary structure checkpoint at anticodon loop modification in tRNA functional maturationHow to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylaseInvestigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as InhibitorFrom lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersHot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzymeReplacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)Molecular basis of cobalamin-dependent RNA modificationCharacterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structureQueuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylaseTransglycosylation: a mechanism for RNA modification (and editing?).Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionBiosynthesis of pyrrolopyrimidines.The role of aspartic acid 143 in E. coli tRNA-guanine transglycosylase: insights from mutagenesis studies and computational modeling.Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesisAlanyl-phosphatidylglycerol synthase: mechanism of substrate recognition during tRNA-dependent lipid modification in Pseudomonas aeruginosa.The queuine micronutrient: charting a course from microbe to man.Site-specific modification of Shigella flexneri virF mRNA by tRNA-guanine transglycosylase in vitroMechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism.Radical-mediated ring contraction in the biosynthesis of 7-deazapurinesProbing the intermediacy of covalent RNA enzyme complexes in RNA modification enzymes.Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivityIdentification of the rate-determining step of tRNA-guanine transglycosylase from Escherichia coli.Conformational change of pseudouridine 55 synthase upon its association with RNA substrate.Queuosine modification of tRNA: its divergent role in cellular machinery.Evolution of cytokinin biosynthesis and degradation.Mechanisms of the tRNA wobble cytidine modification essential for AUA codon decoding in prokaryotes.The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation.Substrate tRNA recognition mechanism of tRNA (m7G46) methyltransferase from Aquifex aeolicus.Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases.Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold.Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA.An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT).Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1
P2860
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P2860
Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Chemical trapping and crystal ...... cosylase covalent intermediate
@ast
Chemical trapping and crystal ...... cosylase covalent intermediate
@en
Chemical trapping and crystal ...... cosylase covalent intermediate
@nl
type
label
Chemical trapping and crystal ...... cosylase covalent intermediate
@ast
Chemical trapping and crystal ...... cosylase covalent intermediate
@en
Chemical trapping and crystal ...... cosylase covalent intermediate
@nl
prefLabel
Chemical trapping and crystal ...... cosylase covalent intermediate
@ast
Chemical trapping and crystal ...... cosylase covalent intermediate
@en
Chemical trapping and crystal ...... cosylase covalent intermediate
@nl
P3181
P356
P1476
Chemical trapping and crystal ...... cosylase covalent intermediate
@en
P2093
Raven H Huang
Xianjun Liu
P304
P3181
P356
10.1038/NSB976
P50
P577
2003-08-31T00:00:00Z