Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
about
Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphatesAlternative modes of binding of proteins with tandem SH2 domainsT-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motifSpecific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activationRapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sortingStructure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinaseMapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kAssociation of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligandGenetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificityCrystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrinSolution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic proteinCrystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexesStructural basis for specificity of Grb2-SH2 revealed by a novel ligand binding modeProtein interaction domains of the ubiquitin-specific protease, USP7/HAUSPDefining the specificity space of the human SRC homology 2 domainThe phospholipase C isozymes and their regulationEpidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytesDifferential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activationAssembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn1H and 15N assignments and secondary structure of the PI3K SH3 domain.Overview of protein structural and functional folds.Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug designProtein-protein interactions: methods for detection and analysisSemi-supervised prediction of SH2-peptide interactions from imbalanced high-throughput data.Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.Electrostatic interactions in the reconstitution of an SH2 domain from constituent peptide fragments.Reconstitution of a native-like SH2 domain from disordered peptide fragments examined by multidimensional heteronuclear NMR.Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase.The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.Random-coil behavior and the dimensions of chemically unfolded proteins.The regulation of class IA PI 3-kinases by inter-subunit interactions.Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.Recent advances on polyproline II.p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.Fluorescence intensity multiple distributions analysis: concurrent determination of diffusion times and molecular brightness.A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.PI 3-kinase: structural and functional analysis of intersubunit interactions.
P2860
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P2860
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
description
1992 nî lūn-bûn
@nan
1992 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
name
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@ast
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@en
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@en-gb
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@nl
type
label
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@ast
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@en
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@en-gb
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@nl
prefLabel
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@ast
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@en
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@en-gb
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@nl
P2093
P356
P1433
P1476
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
@en
P2093
A K Downing
A L Breeze
G Panayotou
G W Booker
I D Campbell
M D Waterfield
P2888
P356
10.1038/358684A0
P407
P50
P577
1992-08-20T00:00:00Z
P6179
1045636554