Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.
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Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinaseEndofin, an endosomal FYVE domain proteinp110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytesInternational Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) familyCCR2 acts as scavenger for CCL2 during monocyte chemotaxisLigand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathwayWortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reactionA role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophagesPlatelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinasePhosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter.Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen.Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.G protein beta gamma subunits stimulate phosphorylation of Shc adapter proteinControlled pseudopod extension of human neutrophils stimulated with different chemoattractants.Cell polarization directed by extracellular cues in yeast.Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.Gi2-mediated activation of the MAP kinase cascade.Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.Chemotactic signaling pathways in neutrophils: from receptor to actin assembly.A human class II MHC-derived peptide antagonizes phosphatidylinositol 3-kinase to block IL-2 signaling.Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeabilityPhosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori.Different sensitivity to wortmannin of two vacuolar sorting signals indicates the presence of distinct sorting machineries in tobacco cells.Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway.Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation.Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cellsStudies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinaseIdentification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.Trivalent ligands with rigid DNA spacers reveal structural requirements for IgE receptor signaling in RBL mast cells.Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cellsIsolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases.Slow self-activation enhances the potency of viridin prodrugsRegulation of sodium-dependent phosphate transport in osteoclasts.Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [(131)I] analogue as useful PET tracers for PI3-kinase.Autophagy inhibitors.The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells.
P2860
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P2860
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
name
Wortmannin binds specifically ...... ling in neutrophil leukocytes.
@ast
Wortmannin binds specifically ...... ling in neutrophil leukocytes.
@en
type
label
Wortmannin binds specifically ...... ling in neutrophil leukocytes.
@ast
Wortmannin binds specifically ...... ling in neutrophil leukocytes.
@en
prefLabel
Wortmannin binds specifically ...... ling in neutrophil leukocytes.
@ast
Wortmannin binds specifically ...... ling in neutrophil leukocytes.
@en
P2093
P2860
P356
P1476
Wortmannin binds specifically ...... ling in neutrophil leukocytes.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.11.4960
P407
P577
1994-05-01T00:00:00Z