The regulation of class IA PI 3-kinases by inter-subunit interactions.
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Phosphoinositides: tiny lipids with giant impact on cell regulationInvestigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutantAssembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src.Too much of a good thing: immunodeficiency due to hyperactive PI3K signalingOncogenic activity of the regulatory subunit p85β of phosphatidylinositol 3-kinase (PI3K)PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advancesKIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumorsPhosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent mannerEPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway.The structural basis of PI3K cancer mutations: from mechanism to therapy.ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.Comparing sequencing assays and human-machine analyses in actionable genomics for glioblastoma.Crossroads of PI3K and Rac pathways.PI3King the right partner: unique interactions and signaling by p110β.Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.GPCR Signaling Mediates Tumor Metastasis via PI3KβPI3Kβ downstream of GPCRs - crucial partners in oncogenesis.The PI3K Pathway in Human Disease.Genes with mutation significance were highly associated with the clinical pattern of patients with breast cancer.Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase.Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ.Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.
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P2860
The regulation of class IA PI 3-kinases by inter-subunit interactions.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The regulation of class IA PI 3-kinases by inter-subunit interactions.
@en
The regulation of class IA PI 3-kinases by inter-subunit interactions.
@nl
type
label
The regulation of class IA PI 3-kinases by inter-subunit interactions.
@en
The regulation of class IA PI 3-kinases by inter-subunit interactions.
@nl
prefLabel
The regulation of class IA PI 3-kinases by inter-subunit interactions.
@en
The regulation of class IA PI 3-kinases by inter-subunit interactions.
@nl
P2860
P356
P1476
The regulation of class IA PI 3-kinases by inter-subunit interactions.
@en
P2093
Jonathan M Backer
P2860
P304
P356
10.1007/82_2010_52
P577
2010-01-01T00:00:00Z