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Inhibition of a mitotic motor protein: where, how, and conformational consequences

Inhibition of a mitotic motor protein: where, how, and conformational consequences

http://www.wikidata.org/entity/Q27642775

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Kinesin-5: cross-bridging mechanism to targeted clinical therapy Mechanistic analysis of the mitotic kinesin Eg5.Monastrol inhibition of the mitotic kinesin Eg5.Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5 NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules Real-time structural transitions are coupled to chemical steps in ATP hydrolysis by Eg5 kinesin Analysis of the interaction of the Eg5 Loop5 with the nucleotide site Pathway of ATP hydrolysis by monomeric kinesin Eg5 ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations Force generation by kinesin and myosin cytoskeletal motor proteins Growing the growth cone: remodeling the cytoskeleton to promote axon regeneration Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex The structure of the ternary Eg5–ADP–ispinesib complex The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5 The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride Optimized S -Trityl- l -cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy Kinesin, 30 years later: Recent insights from structural studies Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol A structural model for monastrol inhibition of dimeric kinesin Eg5.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines Cryo-electron tomography of microtubule-kinesin motor complexes Targeting a kinetochore-associated motor protein to kill cancer cells.Allosteric inhibition of kinesin-5 modulates its processive directional motility.The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5.Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data.Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.Development of new cancer therapeutic agents targeting mitosis.Modular aspects of kinesin force generation machinery Chemistry and biology of multicomponent reactions.Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program.Structures of kinesin motor proteins.

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P2860

Inhibition of a mitotic motor protein: where, how, and conformational consequences

http://www.wikidata.org/entity/Q27642775

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Inhibition of a mitotic motor protein: where, how, and conformational consequences

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

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type

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

@nl

prefLabel

Inhibition of a mitotic motor protein: where, how, and conformational consequences

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

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J.JMB.2003.10.074

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Journal of Molecular Biology

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

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Bei Xu

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Carl Homnick

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Carolyn A Buser

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George D Hartman

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Hans E Huber

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Lawrence C Kuo

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Michael Schaber

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Vinod Sardana

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Wasyl Halczenko

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Youwei Yan

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scholarly article

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10.1016/J.JMB.2003.10.074

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