A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation
about
PARPs and the DNA damage responseA New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human CellsCrystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITYThe DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc FingerStructural studies of the PARP-1 BRCT domainStructural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1Understanding specific functions of PARP-2: new lessons for cancer therapyArsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifsPARP inhibition: PARP1 and beyondAnalyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kappaB-dependent signalingIn Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes.PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.Poly(ADP-ribose) polymerase-1 inhibition: preclinical and clinical development of synthetic lethality.The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoterStructural dynamics in DNA damage signaling and repairIdentification of a regulatory segment of poly(ADP-ribose) glycohydrolase.Targeting poly(ADP-ribose) polymerase activity for cancer therapy.Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases.A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs.New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers.Alternative modes of binding of poly(ADP-ribose) polymerase 1 to free DNA and nucleosomesBinding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates.PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damageTranscriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulationCrosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sitesArsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.The Sound of Silence: RNAi in Poly (ADP-Ribose) ResearchTargeting PARP-1 allosteric regulation offers therapeutic potential against cancer.Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.Conformational activation of poly(ADP-ribose) polymerase-1 upon DNA binding revealed by small-angle X-ray scattering.The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
P2860
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P2860
A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A third zinc-binding domain of ...... NA-dependent enzyme activation
@ast
A third zinc-binding domain of ...... NA-dependent enzyme activation
@en
A third zinc-binding domain of ...... NA-dependent enzyme activation
@nl
type
label
A third zinc-binding domain of ...... NA-dependent enzyme activation
@ast
A third zinc-binding domain of ...... NA-dependent enzyme activation
@en
A third zinc-binding domain of ...... NA-dependent enzyme activation
@nl
prefLabel
A third zinc-binding domain of ...... NA-dependent enzyme activation
@ast
A third zinc-binding domain of ...... NA-dependent enzyme activation
@en
A third zinc-binding domain of ...... NA-dependent enzyme activation
@nl
P2093
P2860
P3181
P356
P1476
A third zinc-binding domain of ...... NA-dependent enzyme activation
@en
P2093
Elizabeth E Rogers
John M Pascal
Kristin M Servent
P2860
P304
P3181
P356
10.1074/JBC.M708558200
P407
P577
2008-02-15T00:00:00Z