about
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexesCrystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine bindingResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesCyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyteThree-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivityCrystal structure of DJ-1/RS and implication on familial Parkinson's diseaseThe crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysisCrystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivityStructural insight into substrate specificity of phosphodiesterase 10The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitorsCrystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitorsConformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and SildenafilHigh-resolution design of a protein loopAn insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studiesKinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡Computer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet DesignInsight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and MutagenesisCrystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1EConformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF DomainStructural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant GlutamineStructure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor DesignDiscovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal StructureBiological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective InhibitorsDual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-MonophosphateDiscovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structureMultiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.Advances in targeting cyclic nucleotide phosphodiesterasesDiscovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agentPhosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite.Structures of calcineurin and its complexes with immunophilins-immunosuppressants.The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.Crystal structures of cyclophilin and its partners.Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric InhibitorCrystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity.Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesteraseInhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.Structural insight into the substrate specificity of phosphodiesterases.
P50
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P50
name
Hengming Ke
@ast
Hengming Ke
@en
Hengming Ke
@nl
type
label
Hengming Ke
@ast
Hengming Ke
@en
Hengming Ke
@nl
prefLabel
Hengming Ke
@ast
Hengming Ke
@en
Hengming Ke
@nl