Structural basis of DNA quadruplex recognition by an acridine drug
about
Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNASolution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug DesignThe crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformationThe high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkagesNMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-QuadruplexG-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomePyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexesVisualization of long human telomere mimics by single-molecule fluorescence imagingDistance measurements between paramagnetic ligands bound to parallel stranded guanine quadruplexesChemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.Identification of novel quadruplex ligands from small molecule libraries by FRET-based high-throughput screening.Single molecule force spectroscopy on G-quadruplex DNAThe many twists and turns of DNA: template, telomere, tool, and target.Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Synthesis of small molecules targeting multiple DNA structures using click chemistry.Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.G-quadruplex structures and their interaction diversity with ligands.Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complexA Personal History of Quadruplex-Small Molecule Targeting.Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.Sequence, stability, and structure of G-quadruplexes and their interactions with drugsSynthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-QuadruplexesMolecular dynamics simulations and coupled nucleotide substitution experiments indicate the nature of A{middle dot}A base pairing and a putative structure of the coralyne-induced homo-adenine duplex.DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.Human telomeric G-quadruplex: structures of DNA and RNA sequences.Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations.Biomolecularmodeling and simulation: a field coming of age.Acridine derivatives: a patent review (2009 - 2010).Methods for investigating G-quadruplex DNA/ligand interactions.The application of DNA and RNA G-quadruplexes to therapeutic medicines.Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes.Fluorescent probes for G-quadruplex structures.Acridine and its derivatives: a patent review (2009 - 2013).Templated Formation of Discrete RNA and DNA:RNA Hybrid G-Quadruplexes and Their Interactions with Targeting Ligands.Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures.Interaction between cationic zinc porphyrin and lead ion induced telomeric guanine quadruplexes: evidence for end-stacking.
P2860
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P2860
Structural basis of DNA quadruplex recognition by an acridine drug
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural basis of DNA quadruplex recognition by an acridine drug
@ast
Structural basis of DNA quadruplex recognition by an acridine drug
@en
Structural basis of DNA quadruplex recognition by an acridine drug
@nl
type
label
Structural basis of DNA quadruplex recognition by an acridine drug
@ast
Structural basis of DNA quadruplex recognition by an acridine drug
@en
Structural basis of DNA quadruplex recognition by an acridine drug
@nl
prefLabel
Structural basis of DNA quadruplex recognition by an acridine drug
@ast
Structural basis of DNA quadruplex recognition by an acridine drug
@en
Structural basis of DNA quadruplex recognition by an acridine drug
@nl
P2093
P356
P1476
Structural basis of DNA quadruplex recognition by an acridine drug
@en
P2093
Anthony P Reszka
Gary N Parkinson
Nancy H Campbell
P304
P356
10.1021/JA8016973
P407
P577
2008-05-28T00:00:00Z