Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex
about
A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.Copper-Oxygen Complexes Revisited: Structures, Spectroscopy, and Reactivity.Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor ActivityConformation-sensitive nucleoside analogues as topology-specific fluorescence turn-on probes for DNA and RNA G-quadruplexes.Analysis of Structure-Activity Relationships Based on the Hepatitis C Virus SLIIb Internal Ribosomal Entry Sequence RNA-Targeting GGHYRFK⋅Cu Complex.Recent advances in targeting the telomeric G-quadruplex DNA sequence with small molecules as a strategy for anticancer therapies.Designing metallodrugs with nuclease and protease activity.Chiral platinum (II)-4-(2,3-dihydroxypropyl)- formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo.Metal complexes promoting catalytic cleavage of nucleic acids-biochemical tools and therapeutics.Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics.Design of Artificial Glycosidases: Metallopeptides that Remove H Antigen from Human Erythrocytes.N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications.Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells.Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination.Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage.Enhanced stability of Cu(2+)-ATCUN complexes under physiologically relevant conditions by insertion of structurally bulky and hydrophobic amino acid residues into the ATCUN motif.A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell.A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic AcidsA phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
P2860
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P2860
Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex
description
2014 nî lūn-bûn
@nan
2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
Toward the design of a catalyt ...... copper-acridine-ATCUN complex
@ast
Toward the design of a catalyt ...... copper-acridine-ATCUN complex
@en
type
label
Toward the design of a catalyt ...... copper-acridine-ATCUN complex
@ast
Toward the design of a catalyt ...... copper-acridine-ATCUN complex
@en
prefLabel
Toward the design of a catalyt ...... copper-acridine-ATCUN complex
@ast
Toward the design of a catalyt ...... copper-acridine-ATCUN complex
@en
P2860
P356
P1476
Toward the design of a catalyt ...... copper-acridine-ATCUN complex
@en
P2093
James A Cowan
Menglu Han
P2860
P304
P356
10.1002/ANIE.201410434
P407
P50
P577
2014-12-11T00:00:00Z