about
Quadruplex DNA: sequence, topology and structureCrystal structure of parallel quadruplexes from human telomeric DNAHighly prevalent putative quadruplex sequence motifs in human DNAThe discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnershipCrystal structure of the potassium form of an Oxytricha nova G-quadruplexStrong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the grooveStructure of a G-quadruplex-ligand complexStructure of the first parallel DNA quadruplex-drug complexStudies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active formStructural basis for binding of porphyrin to human telomeresStructure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit PromoterInduced Fit Conformational Changes of a “Reversed Amidine” Heterocycle: Optimized Interactions in a DNA Minor Groove ComplexObservation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channelStructural basis of DNA quadruplex recognition by an acridine drugTopology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexesSelectivity in ligand recognition of G-quadruplex loopsA G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad DynamicsFluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNAStructural basis of telomeric RNA quadruplex--acridine ligand recognitionSmall-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water ClusterMolecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexesStructural basis for telomeric G-quadruplex targeting by naphthalene diimide ligandsCrystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformationObservation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallographyStructure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cellsCrystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplexStructural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeatsStructural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular TargetG-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomeChemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives
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P50
description
biochemist, pharmacologist
@en
farmacoloog
@nl
name
Stephen Neidle
@ast
Stephen Neidle
@en
Stephen Neidle
@es
Stephen Neidle
@nl
Stephen Neidle
@sl
Stephen Neidle
@sq
type
label
Stephen Neidle
@ast
Stephen Neidle
@en
Stephen Neidle
@es
Stephen Neidle
@nl
Stephen Neidle
@sl
Stephen Neidle
@sq
prefLabel
Stephen Neidle
@ast
Stephen Neidle
@en
Stephen Neidle
@es
Stephen Neidle
@nl
Stephen Neidle
@sl
Stephen Neidle
@sq
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P1006
P214
P244
P1006
P1153
35820006900
P21
P213
0000 0001 0912 2643
P214
P244
P31
P569
1946-01-01T00:00:00Z
P691
mub2010574755
P735
P7859
lccn-n81012836