Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation
about
Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complexDifferent Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡The Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsDisparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding MechanismT Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexTCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicityReconciling views on T cell receptor germline bias for MHCThe molecular basis of TCR germline bias for MHC is surprisingly simpleDynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn miceThe effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.Engineering higher affinity T cell receptors using a T cell display system.The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and functionPlasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRsQuantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope RecognitionStructural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides.Functional implications of T cell receptor diversity.Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders'.A unifying mathematical framework for experimental TCR-pMHC kinetic constants.Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity.Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro.Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.
P2860
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P2860
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Distinct CDR3 conformations in ...... ut not the docking orientation
@ast
Distinct CDR3 conformations in ...... ut not the docking orientation
@en
Distinct CDR3 conformations in ...... ut not the docking orientation
@nl
type
label
Distinct CDR3 conformations in ...... ut not the docking orientation
@ast
Distinct CDR3 conformations in ...... ut not the docking orientation
@en
Distinct CDR3 conformations in ...... ut not the docking orientation
@nl
prefLabel
Distinct CDR3 conformations in ...... ut not the docking orientation
@ast
Distinct CDR3 conformations in ...... ut not the docking orientation
@en
Distinct CDR3 conformations in ...... ut not the docking orientation
@nl
P2093
P2860
P1476
Distinct CDR3 conformations in ...... ut not the docking orientation
@en
P2093
David M Kranz
Jennifer D Stone
K Christopher Garcia
Leremy A Colf
Lindsay L Jones
P2860
P304
P356
10.4049/JIMMUNOL.181.9.6255
P407
P577
2008-11-01T00:00:00Z