T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. - Wikidata - wikimedia - TriplyDB

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.

http://www.wikidata.org/entity/Q37363263

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Large scale characterization of the LC13 TCR and HLA-B8 structural landscape in reaction to 172 altered peptide ligands: a molecular dynamics simulation study Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response Experimental and theoretical bases for mechanisms of antigen discrimination by T cells To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy Indoctrinating T cells to attack pathogens through homeschooling NKG2D ligands as therapeutic targets Mechanical regulation of T-cell functions Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides Recent advances in T-cell engineering for use in immunotherapy Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns.Novel approaches for identifying target antigens of autoreactive human B and T cells Identification of multiple public TCR repertoires in chronic beryllium disease.Physics of cell adhesion: some lessons from cell-mimetic systems.An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.Fast on-rates allow short dwell time ligands to activate T cells.Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses.The basic principles of chimeric antigen receptor design.The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies Specific increase in potency via structure-based design of a TCR.Sequence, structure, function, immunity: structural genomics of costimulation.Engineering improved T cell receptors using an alanine-scan guided T cell display selection system Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control Molecules in medicine mini review: the αβ T cell receptor.Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.T-cell reprogramming through targeted CD4-coreceptor and T-cell receptor expression on maturing thymocytes by latent Circoviridae family member porcine circovirus type 2 cell infections in the thymus.T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells T Cell Receptor Engineering and Analysis Using the Yeast Display Platform.

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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.

http://www.wikidata.org/entity/Q37363263

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on February 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

T-cell receptor binding affini ...... cell activity and specificity.

@en

T-cell receptor binding affini ...... cell activity and specificity.

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type

label

T-cell receptor binding affini ...... cell activity and specificity.

@en

T-cell receptor binding affini ...... cell activity and specificity.

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prefLabel

T-cell receptor binding affini ...... cell activity and specificity.

@en

T-cell receptor binding affini ...... cell activity and specificity.

@nl

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J.1365-2567.2008.03015.X

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T-cell receptor binding affini ...... cell activity and specificity.

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Adam S Chervin

http://www.w3.org/2001/XMLSchema#string

David M Kranz

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Jennifer D Stone

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P2860

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.

Antibody multispecificity mediated by conformational diversity

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

How a single T cell receptor recognizes both self and foreign MHC

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation

The immunological synapse: a molecular machine controlling T cell activation

Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha

T cell receptor signaling precedes immunological synapse formation

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165-176

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scholarly article

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10.1111/J.1365-2567.2008.03015.X

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2

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126

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2009-02-01T00:00:00Z

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23760889

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19125887

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2632691

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