Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
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Lack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signaturesSequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensRevealing the TCR bias for MHC moleculesDifferential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity.Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.Genetic variation in MHC proteins is associated with T cell receptor expression biasesClass II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptorsαβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivityArchitecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.Conserved Vδ1 binding geometry in a setting of locus-disparate pHLA recognition by δ/αβTCRs: insight into recognition of HIV peptides by TCR.Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade.A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.How an alloreactive T-cell receptor achieves peptide and MHC specificity.Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response.Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptor.Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy.Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.A "hotspot" for autoimmune T cells in type 1 diabetes.The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.General Prediction of Peptide-MHC Binding Modes Using Incremental Docking: A Proof of Concept.Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis.In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
P2860
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P2860
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
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name
Structural interplay between g ...... -peptide-MHC cross-reactivity.
@ast
Structural interplay between g ...... -peptide-MHC cross-reactivity.
@en
type
label
Structural interplay between g ...... -peptide-MHC cross-reactivity.
@ast
Structural interplay between g ...... -peptide-MHC cross-reactivity.
@en
prefLabel
Structural interplay between g ...... -peptide-MHC cross-reactivity.
@ast
Structural interplay between g ...... -peptide-MHC cross-reactivity.
@en
P2093
P2860
P356
P1433
P1476
Structural interplay between g ...... R-peptide-MHC cross-reactivity
@en
P2093
Brian M Baker
David M Kranz
Jarrett J Adams
K Christopher Garcia
Leah V Sibener
Marvin H Gee
Sachdev S Sidhu
Samanthi Narayanan
Sydney J Blevins
P2860
P356
10.1038/NI.3310
P407
P577
2015-11-02T00:00:00Z