Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
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Crystal structure of a copper-transporting PIB-type ATPaseTerpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteineRoom-temperature X-ray diffraction studies of cisplatin and carboplatin binding to His15 of HEWL after prolonged chemical exposureInvestigating the Role of Zinc and Copper Binding Motifs of Trafficking Sites in the Cyanobacterium Synechocystis PCC 6803Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxificationThe X-ray structure of the complex formed in the reaction between oxaliplatin and lysozymeEffect of temperature on the interaction of cisplatin with the model protein hen egg white lysozymeDeterminants for simultaneous binding of copper and platinum to human chaperone Atox1: hitchhiking not hijackingCheckMyMetal: a macromolecular metal-binding validation toolCrystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B.The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatinRegulation of Cisplatin cytotoxicity by cu influx transporters.Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitroCopper transporters and the cellular pharmacology of the platinum-containing cancer drugs.Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: a joint mass spectrometry and circular dichroism investigation.Functional partnership of the copper export machinery and glutathione balance in human cells.Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant ResponseAn omics perspective to the molecular mechanisms of anticancer metallo-drugs in the computational microscope era.Cisplatin inhibits MEK1/2.Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.An expanding range of functions for the copper chaperone/antioxidant protein Atox1.Interaction of classical platinum agents with the monomeric and dimeric Atox1 proteins: a molecular dynamics simulation study.Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapyCopper transporter 2 regulates intracellular copper and sensitivity to cisplatinMechanism of tumor resistance to cisplatin mediated by the copper transporter ATP7B.Pt-based drugs: the spotlight will be on proteins.The structural flexibility of the human copper chaperone Atox1: Insights from combined pulsed EPR studies and computations.Exploring Intein Inhibition by Platinum Compounds as an Antimicrobial Strategy.Developing drugs targeting transition metal homeostasis.Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity.Platinum-conjugated antibodies for application in mass cytometry.Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCTR1).Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes.Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila.Structural biology of cisplatin complexes with cellular targets: the adduct with human copper chaperone atox1 in aqueous solution.Interaction of cisplatin and analogue Pt(en)Cl2 with the copper metallo-chaperone Atox1.Platination of the copper transporter ATP7A involved in anticancer drug resistance.Developing multisite empirical force field models for Pt(II) and cisplatin.EPR Spectroscopy Targets Structural Changes in the E. coli Membrane Fusion CusB upon Cu(I) Binding.
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P2860
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@ast
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@en
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@nl
type
label
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@ast
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@en
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@nl
prefLabel
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@ast
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@en
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@nl
P2860
P921
P356
P1476
Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
@en
P2093
Amie K Boal
Amy C Rosenzweig
P2860
P304
P356
10.1021/JA906363T
P407
P577
2009-10-14T00:00:00Z