Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
about
SLC31 (CTR) family of copper transporters in health and diseaseCopper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxificationThe X-ray structure of the complex formed in the reaction between oxaliplatin and lysozymeDeterminants for simultaneous binding of copper and platinum to human chaperone Atox1: hitchhiking not hijackingIn-cell NMR: an emerging approach for monitoring metal-related events in living cells.Roles of Copper-Binding Proteins in Breast Cancer.The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B.Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: a joint mass spectrometry and circular dichroism investigation.Cisplatin inhibits MEK1/2.The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin.A re-evaluation of the role of hCTR1, the human high-affinity copper transporter, in platinum-drug entry into human cellsAn expanding range of functions for the copper chaperone/antioxidant protein Atox1.Interaction of classical platinum agents with the monomeric and dimeric Atox1 proteins: a molecular dynamics simulation study.Translocation of platinum anticancer drugs by human copper ATPases ATP7A and ATP7B.Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapyCopper transporter 2 regulates intracellular copper and sensitivity to cisplatinPt-based drugs: the spotlight will be on proteins.Unresolved questions in human copper pump mechanisms.The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1.Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity.Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes.The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations.Interaction of cisplatin and analogue Pt(en)Cl2 with the copper metallo-chaperone Atox1.On-line coupling of continuous-flow gel electrophoresis with inductively coupled plasma-mass spectrometry to quantitatively evaluate intracellular metal binding properties of metallochaperones HpHypA and HpHspA in E. coli cells.Platinum transfer from hCTR1 to Atox1 is dependent on the type of platinum complex.Identification of binding sites of cisplatin to human copper chaperone protein Cox17 by high-resolution FT-ICR-MS.Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis.A Copper Story: From Protein Folding and Metal Transport to CancerMedicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implicationsCisplatin handover between copper transporters: the effect of reducing agentsAn Updated View of Cisplatin Transport
P2860
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P2860
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@ast
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@en
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@nl
type
label
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@ast
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@en
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@nl
prefLabel
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@ast
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@en
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@nl
P2093
P2860
P356
P1476
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
@en
P2093
Christina Lundin
Christoph F Weise
Erik Björn
Gunnar Wingsle
Magnus Wolf-Watz
Maria E Palm
Yvonne Nygren
P2860
P304
P356
10.1073/PNAS.1012899108
P407
P577
2011-04-11T00:00:00Z