Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
about
Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathyThe Mechanism of Pre-transfer Editing in Yeast Mitochondrial Threonyl-tRNA SynthetaseSide chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressorThe selective tRNA aminoacylation mechanism based on a single G•U pairThe physiological target for LeuRS translational quality control is norvalineEvolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pairp23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasisThe complex evolutionary history of aminoacyl-tRNA synthetases.Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetaseTransfer RNA and human diseaseN-alkylated aminoacyl sulfamoyladenosines as potential inhibitors of aminoacylation reactions and microcin C analogues containing D-amino acids.Mistranslation and its control by tRNA synthetases.Substrate-mediated fidelity mechanism ensures accurate decoding of proline codons.Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defectAncestral AlaX editing enzymes for control of genetic code fidelity are not tRNA-specific.Uneven spread of cis- and trans-editing aminoacyl-tRNA synthetase domains within translational compartments of P. falciparum.Structural analyses clarify the complex control of mistranslation by tRNA synthetasesStructural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases.Lipid II-independent trans editing of mischarged tRNAs by the penicillin resistance factor MurMGenome evolution in the primary endosymbiont of whiteflies sheds light on their divergence.Emergence and evolution.Transfer RNA: a dancer between charging and mis-charging for protein biosynthesis.Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.Deficient activity of alanyl-tRNA synthetase underlies an autosomal recessive syndrome of progressive microcephaly, hypomyelination, and epileptic encephalopathy.Rewiring protein synthesis: From natural to synthetic amino acids.Urea Unfolding Study of E. coli Alanyl-tRNA Synthetase and Its Monomeric Variants Proves the Role of C-Terminal Domain in Stability.Structure-based redesign of proteins for minimal T-cell epitope contentStructural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylationRole of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS.Transfer RNA's latest port of call.Translational fidelity and mistranslation in the cellular response to stress.Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria.Conformational and chemical selection by a trans-acting editing domain.Mechanism of the activation step of the aminoacylation reaction: a significant difference between class I and class II synthetases.Guanidine hydrochloride mediated denaturation of E. coli Alanyl-tRNA synthetase: identification of an inactive dimeric intermediate.Distinct ways of G:U recognition by conserved tRNA binding motifsANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase
P2860
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P2860
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@ast
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@en
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@nl
type
label
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@ast
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@en
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@nl
prefLabel
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@ast
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@en
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@nl
P2093
P2860
P3181
P356
P1433
P1476
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma
@en
P2093
Kirk Beebe
Paul Schimmel
Ryan Shapiro
Xiang-Lei Yang
Yeeting E Chong
P2860
P2888
P304
P3181
P356
10.1038/NATURE08612
P407
P577
2009-12-10T00:00:00Z
P5875
P6179
1027996541